This study investigates pharmacokinetics and drug-drug interaction between Rosuvastatin and Olmesartan in healthy male volunteers
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
36
Single administration of rosuvastatin 20mg tablet QD for 7 consecutive days
Single administration of olmesartan 40mg tablet QD for 7 consecutive days
Co-administration of rosuvastatin 20mg tablet and and olmesartan 40mg tablet QD for 7 consecutive days
Severance Hospital
Seoul, South Korea
Profile of Pharmacokinetics
Css,max, AUCtau
Time frame: 0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 10, 12, 16, 24, 48, 72 hours post-dose with a sample at 72 hr being taken for rosuvastatin only
Profile of Pharmacokinetics
AUCss,last, AUCss,inf, Css,min, T\_1/2
Time frame: 0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 10, 12, 16, 24, 48, 72 hours post-dose with a sample at 72 hr being taken for rosuvastatin only
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