Cardiac resynchronization therapy (CRT) involves pacing the left and right side of the heart in order to improve the coordination of the contraction in patients with heart failure. Current selection criteria incorporate the severity of the symptoms, the mechanical function of the heart and the time it takes the electrical stimulation to spread over the left ventricle (as assessed on the standard 12 lead electrocardiogram-ECG). Unfortunately these criteria only seem to select approximately 70% of the patients who might respond to this invasive therapy. Body surface ECG mapping is a new technique that assesses the electrical activation of the heart in more detail than the standard ECG. This study aims to determine whether this new technology may aid current selection criteria in predicting response to CRT.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
20
Guy's and St Thomas' NHS Foundation Trust
London, United Kingdom
The Royal Brompton and Harefield NHS Foundation Trust
London, United Kingdom
Change in distance travelled during six-minute walk test (6MWT)
Time frame: Baseline and 6 months
Echocardiographic: signs of LV reverse remodelling
Increase by \>5% in left ventricular ejection fraction with an associated decrease in LV end-diastolic (LVEDV) and end-systolic (LVESV) volumes
Time frame: Baseline and 6 months
Symptoms
Change in symptoms severity assessed by Minnesota Living With Heart Failure Questionnaire (MLHFQ)
Time frame: Baseline and 6 months
Neurohormonal status
Change in neurohormonal activation assessed by brain-natriuretic peptide (BNP)
Time frame: Baseline and 6 Months
Pacing
Atrial and ventricular arrhythmic burden, percentage of bi-ventricular pacing
Time frame: 6 months
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