Subclinical hypothyroidism (SCH) is a common condition affecting 3-10% of the general population, especially in women older than 50 years old. It is controversial whether SCH can lead to increased risks of cardiovascular (CV) disease and whether treatment with L-thyroxine reverses these risks. The present study was designed to evaluate the effect of L-thyroxine treatment in SCH on lipid profile, atherosclerosis, endothelial function, serum inflammatory factors and adipocytokines.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
400
Shandong Provincial Hospital
Jinan, Shandong, China
change in lipid profile
Time frame: measured at baseline; 6 month; 12 months and 24 months.
change in thickness of blood vessel wall
Time frame: measured at baseline; 6 months; 12 months and 24 months.
change in endothelial function
Time frame: measured at baseline; 6 months; 12 months and 24 months.
change of adipocytokines
Time frame: measured at baseline; 6 months; 12 months and 24 months.
Change of Oxidative Stress and Chronic Inflammatory Factors Related with Atherosclerosis
Time frame: measured at baseline; 6 months; 12 months and 24 months.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.