The purpose of this study is to determine if reduction in premature ventricular contraction (PVC) burden results in a decrease in blood pressure, sympathetic outflow, plasma catecholamines and an improvement in baroreflex gain. Flecainide will be used for PVC suppression in a randomized, double-blinded, crossover fashion.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
8
Flecainide will be administered to result in a reduction in PVC burden.
Placebo (sugar pills) will be given to result in no alteration in PVC burden.
University of Wisconsin
Madison, Wisconsin, United States
Change in Mean Arterial Pressure
Mean arterial blood pressure was calculated from non-invasive systolic and diastolic arm measurements.
Time frame: Baseline and 28 days
Change in Muscle Sympathetic Nerve Activity
Muscle sympathetic nerve activity was measured as number of bursts of neural activity per 100 heart beats.
Time frame: Baseline and 28 days
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