The Use of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid Cancer

Cyprus University of Technology120 enrolled

Overview

The purpose of this study is to determine whether the use of honey mouthwashes in the prevention of salivary side effects of 131I (radioiodine) therapy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

120

Conditions

Thyroid Cancer

Interventions

thymus honey mouthwashDIETARY_SUPPLEMENT

Based on the intervention, each patient will be instructed to suck 1 or 2 lemon candies every 2-3 h in the daytime plus 4 thymus honey mouthwashes in between (at least one hour after the candy sucking) starting 12 hours after the ingestion of 131I therapy and for a duration of no more than 4 days.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * \>18 years old * They had a histological diagnosis of papillary, follicular, medullary or anaplastic thyroid cancer * They had undergone total thyroidectomy * They were able to provide consent Exclusion Criteria: * patients who had distant metastases, * a history of salivary-gland disorders, * collagen tissue disease * diabetes mellitus, * previous radioiodine therapy or external radiation to the head or neck * allergy to the honey

Locations (1)

Bank of Cyprus Oncology

Nicosia, Nicosia, Cyprus

Outcomes

Primary Outcomes

Grade of sialadenitis

Time frame: Change from Baseline grade of sialadenitis at 6 and 24 months

Secondary Outcomes

Grade of Xerostomia

Time frame: Change from Baseline grade of xerostomia at 6 and 24 months

Level of Health related quality of life

Time frame: Change from Baseline level of health related quality of life at 6 and 24 months

Data from ClinicalTrials.gov

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