Diagnosis of Subclinical Urinary Tract Infections Using Advanced Microbiome Survey Techniques in High Risk Trauma Patients

Mayo Clinic129 enrolled

Overview

The purpose of this study is to see if the investigators can identify early those patients who are admitted to the hospital and have a urinary tract infection (UTI) or those patients that develop a UTI during their hospitalization.

Study Type

OBSERVATIONAL

Enrollment

129

Conditions

Urinary Tract Infection

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 65 years old or older admitted as a result of trauma to Saint Marys Hospital at Mayo Clinic Exclusion Criteria: * Prisoners * Pregnancy * Active urinary tract stones * Less than 65 years of age

Locations (1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Identify of bacteria, genes and proteins that are highly predictive of UTI development

To identify which bacteria, genes and proteins will be highly predictive of UTI development in geriatric trauma patients. We hypothesize that the combination of 16S rDNA and metaproteomics will identify the most informative biosignatures (species/genes/proteins) discerning UTI from asymptomatic bacteriuria.

Time frame: Nine months

Secondary Outcomes

Biomarker candidates for UTIs recalcitrant to antibiotic treatment.

Time frame: Nine months

Morbidity

Time frame: 9 months

Mortality

Time frame: 9 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.