Pharmacodynamic Evaluation of Stool Output Following Oral Administration of Various Low Volume PEG3350-based Gut Cleansing Solutions Using the Split Dose Intake in Healthy Subjects

Inclusion Criteria: 1. The subject's written informed consent must be obtained prior to inclusion. 2. Healthy subjects with an age of 18 to 45 years. 3. Healthy subjects need to be without any history of clinical significant gastrointestinal symptoms by clinical judgement and without the presence of acute abdominal discomfort or symptoms. 4. Females must be surgically sterile, practicing true sexual abstinence or using an acceptable form of effective contraception throughout the study from the following list: contraceptive implants, injectables, oral contraceptives, intrauterine system (IUS), some intrauterine devices (IUDs), vasectomised partner or barrier method (condom or occlusive cap) with spermicidal foam/gel/film/cream/suppository. Hormonal and IUD methods of contraception must be established for a period of 3 months prior to dosing and cannot be changed or altered during the study. All females must have a negative pregnancy test at screening and check-in. 5. Willing, able and competent to complete the entire procedure and to comply with study instructions. Exclusion Criteria: 1. Use of laxatives in the last 12 months or colon motility altering drugs in the last 6 months. 2. Use of any prescription or over-the-counter (OTC) medication within 4 weeks prior to the first dose of investigational drug (excluding hormonal contraception, and occasional use of nonsteroidal anti-inflammatory drugs \[NSAID\], acetaminophen or metamizole). 3. Donation or loss of 500 mL or more of blood within 8 weeks prior to the first dose of investigational drug. 4. Any evidence of the history or presence of organic or functional gastrointestinal conditions (e.g. chronic constipation, irritable bowel syndrome \[IBS\], inflammatory bowel disease \[IBD\]). 5. Exhibiting relevant abnormal gastrointestinal motility according to clinical judgement in the past or now. 6. History or presence of any clinically significant acute illness within the 4 weeks prior to the first dose of investigational drug based on clinical judgement at screening and check-in evaluation. 7. Known glucose-6-phosphatase dehydrogenase deficiency. 8. Known phenylketonuria. 9. History or evidence of any clinical significant systemic cardiovascular, hepatic, pulmonal, neurological, metabolic and/or renal organ dysfunction. 10. History of clinically significant drug allergy; history of atopic allergy (asthma, urticaria, eczematous dermatitis), known hypersensitivity to polyethylene glycols and/or ascorbic acid. 11. History or evidence of any clinically relevant electrocardiogram (ECG) abnormalities and hypertension. 12. Evidence of dehydration. 13. Any evidence for abnormal sodium or potassium levels or clinically significant other electrolyte disturbances. 14. Females who are pregnant, having a positive pregnancy test at screening and/or admission to unit or planning a pregnancy. Females not using reliable methods of birth control. 15. Clinically relevant findings on physical examination based on Investigator's judgement. 16. Clinically relevant deviations of laboratory parameters from reference ranges at screening or check-in evaluation. 17. Positive serology for chronic viral hepatitis or human immunodeficiency virus (HIV) at screening. 18. History of drug or alcohol abuse within the 12 months prior to dosing or evidence of such abuse as indicated by the laboratory assays conducted during the screening or check-in evaluations. 19. Subjects who are unwilling to comply with the provisions of the study protocol. 20. Concurrent participation in an investigational drug study or participation within 3 month of study entry. 21. Subject has a condition or is in a situation, which in the Investigators opinion may put the subject at significant risk, may confound the study results, or may interfere significantly. 22. Previous participation in the study.