Patellar Tendinopathy - Effect of Training and Enhancement of the Collagen Synthesis by Insulin-like Growth Factor-I

Early Phase 1UnknownNCT01834989

Bispebjerg Hospital40 enrolled

Overview

The purpose of the study is to test the hypothesis that stimulation of the synthesis of new structural tendon proteins combined with training improve the tendon structure in patients with chronic knee tendon pain.

Randomized controlled intervention study: 12 weeks intervention period with training and injections of saline or Insulin-Like growth factor I. One year follow-up

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Tendinopathy

Interventions

Insulin-like growth factor IDRUG

PlaceboDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * chronic patellar tendinopathy (\> 3 months) * anterior-posterior thickening of the tendon (1 mm compared to mid-tendon) * hypo-echoic area with enhanced vascularization Exclusion Criteria: injection * corticosteroid injection within the last 12 months * Knee operation * Knee osteoarthritis * Diabetes * Smoking * Body mass index \>30

Locations (1)

Institute of Sports Medicine, Copenhagen

Copenhagen, Denmark

Outcomes

Primary Outcomes

Tendon structure

Time frame: After 12 weeks intervention (tendon biopsy)

Secondary Outcomes

Tendon Pain

questionnaire

Time frame: 1 year (before and after 12 weeks intervention and 1 year after intervention start)

Data from ClinicalTrials.gov

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