Breath Gas Measurement of Propofol During Anesthesia in Patients With Endourological Procedures

University of Luebeck22 enrolled

Overview

Propofol can be measured continuously in breath gas during anesthesia. This study compares propofol concentration in plasma and breath gas and processed electroencephalographic monitoring (bispectral index) under clinical conditions with patients and total intravenous anesthesia. Target controlled infusion technique is used to deliver adequate propofol concentration in plasma.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Urological Disease

Interventions

Drug: Propofol Anesthesia Patients will undergo propofol anesthesia.DEVICE

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: • 18 years of age * Written informed consent * Ability and willingness to give written informed consent * American Society of Anesthesiologists (ASA) risk score I-II Exclusion Criteria: * Denial of the patient * Patients ASA physical status III- IV * Pregnancy * Volunteers with history of neurological disease or stroke * Volunteers with a history of recreational drug abuse * Volunteers with a history of alcohol abuse * Known drug allergies * History of adverse events during general anesthesia * Total intravenous anesthesia not practicable

Locations (1)

Dept. of Anesthesiology and Intensive Care

Lübeck, Schleswig-Holstein, Germany

Outcomes

Primary Outcomes

Exhaled propofol (parts per billion)

Time frame: Continuous measurement over 40 min during the induction of anesthesia and 30 min during recovery of anesthesia

Data from ClinicalTrials.gov

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