Continued Safety and Performance of the TIVUS System

Inclusion Criteria: * Patient is ≥ 18 and ≤ 80 years of age * For Cohort A: Documented office systolic blood pressure \> 160 mmHg (\> 150 mmHg for diabetic patients); For Cohort B: Documented office systolic blood pressure \> 140 mmHg (\> 130 mmHg for diabetic patients); For Cohort C: Documented office systolic blood pressure \> 150 mmHg (\> 140 mmHg for diabetic patients) * Documented 24 hour systolic ABPM \> 135 mmHg * Adherence to a stable drug regimen * For patients in Cohort C only: Documented renal denervation procedure with any RF technology 12 months or more prior to screening * Suitable renal artery anatomy * Male or non-pregnant / non-lactating female * Patient understands the nature of the procedure and provides written informed consent * Patient is willing and able to comply with the specified study requirements and follow-up evaluations Exclusion Criteria: * eGFR \< 45mL/min/1.73m2 * Documented primary pulmonary hypertension * Patient experienced \>1 episode of orthostatic hypotension coupled with syncope * Documented indicator of a secondary renal hypertension * History of myocardial infarction, unstable angina pectoris, or a cerebrovascular accident within 6 months * Planned major surgery or cardiovascular intervention in the next 6 months * Surgery or cardiovascular intervention in the previous 3 months * Hemodynamically significant valvular heart disease * Severe debilitating lung disease * Patient on anticoagulant therapy that cannot be temporarily withheld for performing catheterization * Patient has a single functioning kidney * Documented thrombocytopenia, clotting disorders or aortic aneurysms * Moribund patient, or patient with comorbidities limiting life expectancy to less than one year * Contraindication to recommended study medications or intravascular contrast material that cannot be adequately controlled with pre-medication * Concurrent enrollment in another trial * Main renal arteries \< 4 mm in lumen diameter or \< 20 mm in length * Aorto-renal angle that prevents a safe cannulation of the renal artery * Severe common femoral artery, common and/or external iliac artery, renal, iliac or aortic calcification or tortuosity that may compromise the safe performance and completion of the procedure * Hemodynamically or anatomically significant renal artery abnormality or stenosis in either renal artery * Any renal artery stenosis \> 50% by visual assessment * Any renal artery aneurysm in either renal artery * A history of prior renal artery balloon angioplasty or stenting (for patients in Cohort A and B only, also a history of prior renal denervation at any time)