This study is to research two questions. First, is vitamin D3 more effective than vitamin D2 in raising 25-hydroxyvitamin D \[25(OH)D\] levels in chronic kidney disease (CKD) patients? And secondly, what are the differential effects of vitamin D2 and vitamin D3 on other mineral metabolism parameters?
Vitamin D helps form and strengthens bones by allowing the body to absorb calcium. Vitamin D helps the immune system fight infection as well as helps keep muscles strong. Without enough vitamin D, bones can become weak, thin and brittle. Vitamin D is useful in people with various types of health issues. Patients with CKD exhibit an unusually high rate of vitamin D deficiency, which may contribute to some of the poor clinical outcomes in this group. This study will randomize patients with CKD and low vitamin D levels to two groups; one group will be treated with vitamin D2 (ergocalciferol) and the other group will be treated with vitamin D3 (cholecalciferol). The purpose of this study is to compare the effects of the two different forms of vitamin D specifically in patients chronic kidney disease.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
44
50,000 units once a week for 12 weeks
50,000 units once a week for 12 weeks
University of Kansas Medical Center
Kansas City, Kansas, United States
Change in total serum 25-hydroxyvitamin D [25(OH)D] levels (ng/mL)
Time frame: Baseline to immediately post-therapy (week 12)
Change in serum 25-hydroxyvitamin D2 and D3 subfractions (ng/mL)
Time frame: Baseline to immediately post-therapy (week 12), and week 12 to week 18
Change in total serum 25(OH)D (ng/mL)
Time frame: week 12 to week 18
Change in serum intact parathyroid hormone (PTH) (pg/mL)
Time frame: Baseline to week 12
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