Understanding Disparities in Quitting in African American and White Smokers

Inclusion Criteria: * Non-Hispanic African American or non-Hispanic White * ≥ 18 years of age * Smoked 3-20 cigarettes per day * Smoked on \>25 days of the past 30 days * Functioning telephone * Interested in quitting smoking * Interested in taking 3 months of varenicline * Willing to complete all study visits Exclusion Criteria: * Renal impairment * Evidence or history of clinically significant allergic reactions to varenicline * A cardiovascular event in the past month Hospitalization in the past 2 months for any cardiovascular disease, including but not limited to: * Angina * Myocardial infarction * Peripheral vascular disease * Stroke * New onset of chest pain or arrhythmia in the past 2 months * History of alcohol or drug dependency in the past year * Major depressive disorder in the last year requiring treatment * History of panic disorder, psychosis, bipolar disorder, or eating disorders * Use of tobacco products other than cigarettes in past 30 days * Use of pharmacotherapy in the month prior to enrollment, including prior use of varenicline * Pregnant, contemplating getting pregnant, or breastfeeding * Plans to move from Kansas City during the treatment and follow-up phase * Another household member enrolled in the study