Prevalence of Toxoplasma Gondii and Toxocara Canis Among Patients With Uveitis

National Institute of Health, Korea98 enrolled

Overview

Investigate the prevalence of Toxoplasma gondii and Toxocara canis in Uveitis * serum antibody to T. gondii and T. canis * PCR with peripheral blood for T. gondii and T. canis * PCR with aqueous humor for T. gondii and T. canis * Clinical manifestation of patient with uveitis

Consecutive patients with uveitis are enrolled in Nune Eye Hospital. Serum ELISA * IgM,IgG antibody to Toxoplasma gondii * IgG antibody to Toxocara canis PCR * PCR with serum and aqueous humor to Toxoplasma gondii * PCR with serum and aqueous humor to Toxocara canis Clinical characteristics * visual acuity * intraocular pressure (IOP) * location and degree of inflammation * other fundus findings were recorded questionnaire * environment, occupation * pet ownership, exposure to animal * history of eating raw liver of animal, raw beef or any other raw flesh of animal.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Uveitis

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * patients with uveitis Exclusion Criteria: * Patients with history of major ophthalmic surgery within 6 months * antiviral, antifungal or antiparasitic therapy within 6 months

Outcomes

Primary Outcomes

Number of patients with positive result for serum antibody to Toxoplasma gondii and Toxocara canis

proportion of patients with seropositive for Toxoplasma gondii and Toxocara canis among patients

Time frame: at baseline

Secondary Outcomes

Number of patients with positive PCR with peripheral blood and aqueous humor to Toxoplasma gondii and Toxocara canis

Proportion of patient with positive PCR to Toxoplasma gondii and Toxocara canis

Time frame: at baseline

Data from ClinicalTrials.gov

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