In this study, we wish to investigate the effect of ultrasound (US) -guided block of the saphenous nerve (SN) and the posterior branch of the obturator nerve (ONP) on postoperative pain and the use of opioids (morphine-like pain medicine) in the first 24 hours following ambulatory knee arthroscopy. We wish to investigate the analgesic effect of these two blocks compared to placebo (injection of local anesthetic with known pain blocking properties compared with injection of a saline solution), when used as a supplement to conventional oral analgesics. We hypothesize that patients receiving the active treatment may experience less pain during the first 24 hours after their operation than patients receiving the placebo treatment, and possibly require less opioid analgesics, experience less opioid related side effects and have a higher function level in this period than patients receiving the placebo treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
60
7.5 ml of Ropivacaine 7.5 mg/ml injected at each site
7.5 ml of isotonic saline solution 154 mmol/l injected at each site
5 mg as needed
4 mg i.v. as needed in the PACU
10 mg tablet as needed in the postoperative period after discharge from the PACU
Department of Anesthesiology, Bispebjerg Hospital
Copenhagen, Denmark
Pain on knee flexion
VRS (Verbal Rating Scale) score 0-10 on active flexion of the knee to 45 degrees, measured at 0, ½, 1, 2, 3, 4, 6, 8, 12 and 24 hours postoperatively and analyzed by area under curve (AUC) analysis.
Time frame: 24 hours postoperatively
Pain at rest
VRS (verbal rating score) 0-10 at rest, measured at 0, ½, 1, 2, 3, 4, 6, 8, 12 and 24 hours postoperatively and analyzed by area under curve (AUC) analysis.
Time frame: 24 hours postoperatively
Time to opioid intake
First time the patient needs to take supplementary opioids in the postoperative period
Time frame: 24 hours postoperatively
Total opioid intake
Total dose of opioids taken in the first 24 hours postoperatively
Time frame: 24 hours
Nausea
VRS score 0-10, measured at 0, ½, 1, 2, 3, 4, 6, 8, 12 and 24 hours postoperatively and analyzed by area under curve (AUC) analysis.
Time frame: 24 hours postoperatively
Vomiting
Number of times the patient has vomited in the first 24 hours postoperatively.
Time frame: 24 hours
Use of antiemetics
Total dose of antiemetics taken during the first 24 hours postoperatively
Time frame: 24 hours
PACU length of stay
Total length of stay in the post anesthetic care unit (PACU) after the operation.
Time frame: 24 hours
Function level: Barthel Index/100
Modified Barthel Index/100 score 24 hours after the operation.
Time frame: 24 hours
Function level: Short form (SF) -8
Short form (SF) -8 questionnaire 24 hours postoperatively
Time frame: 24 hours
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