Probiotics in the Treatment of Irritable Bowel Syndrome

Islamic Azad University, Najafabad Branch82 enrolled

Overview

Some evidences have shown that probiotics are effective in the treatment of irritable bowel syndrome. Because few evidences are available in our population, we investigated if probiotics are effective in our patients as well. We hypothesize that the probiotic Lactol which contains Lactobacillus Sporogenes reduces the symptoms of irritable bowel syndrome.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Irritable Bowel Syndrome

Interventions

LactolDRUG

The Symbiotic Lactol® (Bioplus Life Sciences Pvt.) was applied 3 times a day for 3 months. Lactol is composed of the followings; Lactobacillus Sporogenes (15 × 107 Spores), Fructo-Oligosaccharides, Microcrystalline Cellulose, Sodium starch Glycolate, Povidone, Hypermellose Stearate, Sillicon Dioxide, and Propylene Glycol.

PlaceboDRUG

Placebo pill was applied 3 times a day for 3 months

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age between 18 and 65 * diagnosis of IBS based on the Rome III criteria * willingness to participate Exclusion Criteria: * receiving other probiotics compound during the study * receiving antibiotics during the study

Locations (1)

Shariati Hospital

Isfahan, Isfahan, Iran

Outcomes

Primary Outcomes

Abdominal pain

Abdominal pain was assessed by Rome III questionnaire at baseline and then after 3 months.

Time frame: Up to 3 months

Constipation

Constipation was assessed by Rome III questionnaire at baseline and then after 3 months.

Time frame: Up to 3 months

Diarrhea

Diarrhea was assessed by Rome III questionnaire at baseline and then after 3 months.

Time frame: Up to 3 months

Data from ClinicalTrials.gov

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