Aim of the study is a description of changes in platelet function during continuous veno-venous hemodialysis or hemofiltration in patients on an intensive care unit using the Multiplate system.
Study Type
OBSERVATIONAL
Enrollment
50
Johann Wolfgang Goethe-University
Frankfurt am Main, Hesse, Germany
ASPItest
Area under the aggregation curve (AUC) after platelet stimulation with arachidonic acid at baseline and 6, 12, 24 and 48 hours after the start of the continuous hemofiltration.
Time frame: Baseline, 6, 12, 24 and 48 hours
ADPtest
Area under the aggregation curve (AUC) after platelet stimulation with adenosine diphosphate at baseline and 6, 12, 24 and 48 hours after the start of the continuous hemofiltration.
Time frame: Baseline, 6, 12, 24 and 48 hours
TRAPtest
Area under the aggregation curve (AUC) after platelet stimulation with thrombin-receptor-activating peptide 6 (TRAP-6) at baseline and 6, 12, 24 and 48 hours after the start of the continuous hemofiltration.
Time frame: Baseline, 6, 12, 24, 48 hours
CT-INTEM
Clotting time (CT) in the intrinsically activated rotational thrombelastometry (ROTEM) recorded in seconds at baseline and 6, 12, 24 and 48 hours after the start of continuous veno-venous hemofiltration.
Time frame: Baseline, 6, 12, 24 and 48 hours
MCF-INTEM
Maximum clot firmness (MCF) in the intrinsically activated rotational thrombelastometry (ROTEM) recorded in millimeters at baseline and 6, 12, 24 and 48 hours after the start of continuous veno-venous hemofiltration.
Time frame: Baseline, 6, 12, 24 and 48hours
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