The purpose of this study is to investigate the effect of a daily supplement consisting of the probiotic bacteria, Lactobacillus reuteri, on the digestive health among persons 65 years and older.
The overall purpose of the study is to investigate the effect of daily supplementation, during a three months period, of L. reuteri on digestive health in an elderly Swedish population, residing in the municipality of Örebro. In addition an extensive screening of the study population in regard of overall health status, functionality and well-being as well as the composition of the gut microbiome will be assessed prior study start through the collection of baseline data
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
290
Galactooligosaccharide (GOS) and rhamnose in a powder formulation
Lactobacillus reuteri DSM17938, Galactooligosaccharide (GOS), rhamnose in a powder formulation
Örebro University
Örebro, Närke, Sweden
Change from baseline Gastrointestinal symptoms to 3months
Gastrointestinal discomfort will be assessed through the gastrointestinal symptoms rating score (GSRS), a clinical rating scale for gastrointestinal symptoms. The GSRS includes 15 symptoms and uses a 7-point Likert scale in which 1 represents the most positive option and 7 the most negative.
Time frame: Baseline, at 2 months and at 3months/study end
Change in use of intestinal motility regulating substances during the 3-month intervention period
Intestinal motility regulating substances (e.g anti-diarrheal and anti-constipation medication)
Time frame: at baseline and end of study ( 3months)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.