Brain Perfusion in Pantothenate Kinase-associated Neurodegeneration (PKAN)

Susan J. Hayflick10 enrolled

Overview

The purpose of this study is to learn whether blood flow in the brain is normal in people with pantothenate kinase-associated neurodegeneration (PKAN). Specifically, preliminary data suggest a region of the brain called the globus pallidus (GP), a key region affected by PKAN, may have reduced blood flow. Standard MRI and perfusion scanning techniques will be used to learn about cerebral blood flow in the globus pallidus and compare it to blood flow in other brain regions as well as to healthy controls.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pantothenate Kinase-associated Neurodegeneration (PKAN)

Eligibility

Sex: ALLMin age: 7 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * diagnosis of PKAN confirmed by MRI and gene testing * able to undergo MRI for approximately 1 hour without sedation Exclusion Criteria: * deep brain stimulators or other conditions that warrant avoidance of a strong magnetic field * previous reaction to gadolinium (Gd) contrast agent * acute or chronic kidney dysfunction * pregnant and/or nursing at time of study

Locations (1)

Oregon Health & Science University

Portland, Oregon, United States

Outcomes

Primary Outcomes

ASL-derived cerebral blood flow(CBF)

The unit of analyses will be the subject and the primary comparison will be the globus pallidus CBF between PKAN and healthy controls.

Time frame: Single MRI

Data from ClinicalTrials.gov

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