Intracranial Atherosclerosis and Depression After Coronary Artery Bypass Graft

Yale University169 enrolled

Overview

The purpose of the study is to examine if blood flow in the brain before coronary artery bypass graft surgery has an effect on depression after surgery. The main hypothesis of the study states that pre-surgical blood flow in the brain will be an independent risk factor for depression after surgery after adjusting for other risk factors such as gender, pre-CABG depression, social support, medical comorbidity burden, socioeconomic status, and neuroticism.

Study Type

OBSERVATIONAL

Enrollment

169

Conditions

Depression Intracranial Atherosclerosis Coronary Artery Disease

Eligibility

Sex: ALLMin age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age: 40 years or older * Will be having CABG surgery at the Yale New Haven Hospital * Be able to provide informed consent * Have a household telephone * A fluent English speaker, and possessing no communication barrier * Be able to come to the study site or to have the study team come to his/her home. * Has a family member or partner/ friend who could provide collateral information Exclusion Criteria: * Has had previous CABG surgery * History of dementia diagnosis or cognitive impairment (CDR \>/= 1) * Auditory or visual impairment that would interfere with study procedures * Active alcohol or substance abuse problem based CAGE-AID (endorsing two or more items) * History of Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, or any Psychotic Disorder by medical history or self-report. * Presence of non-cardiovascular conditions likely to be fatal within 1 year

Locations (2)

Yale University School of Medicine

New Haven, Connecticut, United States

The Johns Hopkins University

Baltimore, Maryland, United States

Outcomes

Primary Outcomes

Pre-surgical intracranial atherosclerosis as measured by transcranial doppler ultrasound relative to depressive symptoms post-surgically as measured by DISH.

Time frame: 12 months

Secondary Outcomes

Examine neurocognitive function relative to post-CABG depression through a series of neurocognitive tests.

Neurocognitive tests are aimed at evaluating memory, processing speed, and global cognition.

Time frame: 12 months

Data from ClinicalTrials.gov

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