To evaluate the feasibility and efficiency of zero ischemia laparoscopic radio frequency ablation assisted enucleation of T1a renal cell carcinoma in comparison with the conventional laparoscopic partial nephrectomy.
Warm ischemic injury is one of the most important factors affecting renal function in partial nephrectomy (PN). Zero ischemia partial nephrectomy technique using renal arterial branch microdissection could protect renal function during surgery, but it requires longer operative time and more blood loss than conventional partial nephrectomy. The technique of zero ischemia laparoscopic radio frequency ablation assisted enucleation of renal cell carcinoma appears to be an alternative that eliminates warm ischemia, preserves the maximal parenchyma and is oncologically safe. Our study was designed to evaluate this technique in comparison with the conventional laparoscopic partial nephrectomy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
90
conventional laparoscopic partial nephrectomy
RenJi Hospital
Shanghai, Shanghai Municipality, China
RECRUITINGthe absolute change in glomerular filtration rate (GFR) of the affected kidney
12 months minus baseline
Time frame: baseline and 12 months
estimated GFR (eGFR)
Time frame: 12 months
changes in GFR of total kidneys by renal scintigraphyby
Time frame: baseline and 12 months
blood loss
Time frame: during surgery
surgical margin
pathologic confirm of surgical margin
Time frame: postoperative
postoperative complications
Time frame: 12 months
progression-free survival
Time frame: 12 months
local recurrence
Time frame: 12 months
the absolute change in glomerular filtration rate (GFR) of the affected kidney
6 months minus baseline
Time frame: baseline and 6 months
estimated GFR (eGFR) of 6 month
Time frame: 6 month
changes in GFR of total kidneys by renal scintigraphyby of 6 month
Time frame: 6 month
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