The Effect of Antihypertensive Agents Concerning With Hemodynamics and Reduction of Anaesthetics in Orthognathic Surgery

Yonsei University75 enrolled

Overview

For those who receive hypotensive anesthesia in orthognathic surgeries, the investigators premedicate with anti-hypertensive agent so that it decreases the occurence of tachycardia and the rebound hypertension due to hypotensive anesthesia, enabling us to compare hemodynamic stability and reduction of anesthetic agents during the operation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Orthognathic Surgery

Interventions

b-blocker(Atenolol)DRUG

ACE inhibitor(Enapril)DRUG

controlOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 29 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. ASA class I-II 2. obtaining written informed consent from the parents 3. aged 18-29 years who were undergoing orthognathic surgery. Exclusion Criteria: 1. Hypertension patients with anti-hypertensive agents 2. chronic renal failure or End stage renal disease patients. 3. renal artery stenosis history. 4. Patients who are with medication due to systemic disease. 5. symptomatic asthma 6. Drug hyperactivity 7. neurological or psychiatric illnesses 8. mental retardation 9. patients who can't read the consent form due to illiterate or foreigner

Locations (1)

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine

Seoul, Seoul, South Korea

Outcomes

Primary Outcomes

the influence of antihypertensive agents on hemodynamic stability

Total minutes when the MAP is lower than 55mmHg and higher than 65mmHg (min) , The time below 55 mmHg(min) , The total time above 65 mmHg (min) Total remifentanil amount, total NTG amount, total phenylephrine amount Arterial gas analysis 4 times after induction, at the start of manipulation of mandible, at the start of manipulation of maxilla, at the end of surgery. Pr-operative and post-operative lab (Hb, Bun, Cr, OT, PT, Na, K) Intraoperative total fluid, total urine amount, total blood loss, transfusion amount.

Time frame: From the beginning until the end of hypoetensive anesthesiaan expected average of 65 mins.(From manipulration of Mandible to maxilla)

Secondary Outcomes

reduction of anaesthetics with control

Time frame: From the beginning until the end of hypoetensive anesthesia an expected average of 65 mins.(From manipulration of Mandible to maxilla)

Data from ClinicalTrials.gov

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