Biological Rhythms and Vestibular System

University Hospital, Caen96 enrolled

Overview

The purpose of this study is to study the relationship between the vestibular system and chronobiology

The purpose of this study is to study the relationship between the vestibular system and chronobiology. Two parts will be performed. In the first one patients with bilateral vestibular areflexia will be compared to control subjects. In the second the effect of vestibular stimulation on circadian rhythms will be evaluated

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Unspecified Disorder of Vestibular Function, Bilateral

Interventions

vestibular stimulationBEHAVIORAL

Physical activity and vestibular stimulation will be used in order to improve circadian rhythms

Eligibility

Sex: ALLMin age: 20 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * No treatment changing vigilance/wakefulness * Moderate caffein uptake (2 to 3 cups a day) * Moderate smoker (5 cigarettes a day) * Regular sleeping habits Exclusion Criteria: * Sleeping duration \<6 hours or \>9 hours * Night workers * Pregnancy * Sleep or wakefulness disorders * Progressive neurodegenerative disorders * Progressive psychiatric disorders * Thyroid disease * Type 1 diabetes * Not able to practice physical activity * Drug or alcohol addiction during the last 6 months

Locations (1)

Umr Ucbn/Inserm U1075 Comete

Caen, Basse-Normandie, France

RECRUITING

Outcomes

Primary Outcomes

Measurements of vestibular reflexes (ocular and spinal) and circadian rhythms of biological functions.

Gain of vestibular ocular reflex Amplitude of vestibular spinal reflex Amplitude and phase of temperature circardian rhythms

Time frame: 3 years

Central Contacts

Pierre Denise, MD PhD

CONTACT

33231068214 pierre.denise@unicaen.fr

Data from ClinicalTrials.gov

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