The main objective of the study is to estimate and compare the percentage of patients with abnormal glucose metabolism at 4-12 weeks postpartum between two groups: patients diagnosed with gestational diabetes before or after 24 weeks of pregnancy. Abnormal glucose metabolism is defined as type 2 diabetes, glucose intolerance or impaired fasting glucose.
The secondary objectives of this study are to compare between the two groups: A. the rate of type 2 diabetes only, glucose intolerance only, impaired fasting glucose only, and patients requiring insulin at 4-12 weeks postpartum B. rates of maternal and obstetric complications C. risk factors (age, body mass index, personal history of gestational diabetes or macrosomia, first degree family history of diabetes). D. For fasting glucose done before 24SA, we will calculate the optimal threshold for predicting abnormal glucose metabolism in the immediate postpartum period among women with gestational diabetes.
Study Type
OBSERVATIONAL
Enrollment
500
All patients will have an oral glucose tolerance test at 4 to 12 weeks after the end of pregnancy. Study representatives will contact patients by phone to remind them of the necessity of this test, and its importance for their health.
CH d'Arles - Hôpital Joseph Imbert
Arles, France
CHU de Montpellier - Hôpital Arnaud de Villeneuve
Montpellier, France
CHU de Montpellier - Hôpital Lapeyronie
Montpellier, France
CHU de Nîmes - Hôpital Universitaire Carémeau
Nîmes, France
Presence/absence of abnormal glucose metabolism
Includes type 2 diabetes, glucose intolerance and impaired fasting glucose
Time frame: 4 to12 weeks post-partum
Presence/absence of type 2 diabetes
Time frame: 4 to 12 weeks post partum
Presence/absence of glucose intolerance
Time frame: 4 to 12 weeks post-partum
Presence/absence of impaired fasting glucose
American definition: defined as between 1 and 1.26 g/l
Time frame: 4 to12 weeks post-partum
Presence/absence of impaired fasting glucose
European definition: defined as between 1.1 and 1.26 g/l
Time frame: 4 to12 weeks post-partum
Patient requiring insulin: yes/no
Time frame: 4 to12 weeks post-partum
Presence/absence of complications
This includes a yes/no response for each of the following: caesarean section, hypertension, preeclampsia, urinary tract infection, macrosomia, dystocia, neonatal transfer, respiratory distress, threat of premature birth.
Time frame: 4 to12 weeks post-partum
Baby's weight at birth (kg)
Time frame: 4 to 12 weeks post-partum
Weeks of amenorrhea (duration of pregnancy in weeks/ gestational age)
Time frame: 4 to 12 weeks post-partum
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Patient was older than 35 years of age at beginning of pregnancy? yes/no
Time frame: baseline (day 0)
Body mass index > 25 at beginning of pregnancy? yes/no
Time frame: baseline (day 0)
First degree family history of type 2 diabetes? yes/no
Time frame: baseline (day 0)
History of gestational diabetes? yes/no
Time frame: baseline (day 0)
History of macrosomia? yes/no
Time frame: baseline (day 0)
Fasting glucose (g/l)
Time frame: before 24 weeks of amenorrhea
Oral glucose tolerance test results if necessary
Time frame: 24 to 28 weeks of amenorrhea