Prediction of Hemodynamic Reactivity During General Anesthesia Using Analgesia/Nociception Index (ANI)

Hôpital Edouard Herriot100 enrolled

Overview

The aim of this study is to evaluate the performance of Analgesia/Nociception Index for the prediction of hemodynamic reactivity in adult patients undergoing ear-nose-throat or lower limb orthopedic surgery on desflurane/remifentanil general anesthesia.

Measurement of analgesia/nociception index at different time points during procedure and assessment of analgesia/nociception index to predict hemodynamic reactivity by building receiver observer's characteristic curve.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Anesthesia

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18-75 years * Ear-nose-throat or lower limb surgery * General anesthesia using desflurane and remifentanil Exclusion Criteria: * Age \<18 yrs or \>75 yrs * Arrythmia * Preoperative use of B-blockers * Administration of anticholinergic drugs or neuromuscular blockade reversal in the 20 previous minutes * Psychiatric diseases * Autonomic nervous system disorders (epilepsy)

Locations (1)

Hôpital Édouard Herriot, HCL

Lyon, Rhône, France

Outcomes

Primary Outcomes

Change in heart rate and/or systolic blood pressure by more than 20% within 5 minutes

Time frame: Before induction of anesthesia, 1 min after incision, at steady-state anesthesia during procedure (an expected average of 30 min) and at arousal from general anesthesia in the end of procedure (an expected average of 60 min)

Data from ClinicalTrials.gov

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