The aim of this study is to find which is the best nutritional strategy in cancer patients undergoing abdominal surgery regarding postoperative complications.
There is a controversy regarding the timing of initiation of parenteral nutrition in cancer patients undergoing abdominal surgery in whom caloric targets cannot be met by enteral nutrition alone. This is a randomized and controlled trial comparing early initiation with late initiation of parenteral nutrition. Early-initiation group: patients will be randomized to initiate parenteral nutrition in the 2nd day after surgery. Late-initiation group: patients will be randomized to initiate parenteral nutrition in the 7th day after surgery. Calculations regarding the caloric goal included protein energy and were based on corrected ideal body weight, age and sex. When oral or enteral nutrition covered 80% of the calculated caloric goal, parenteral nutrition was reduced and progressively stopped.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
335
Cancer Institute of the State of Sao Paulo
São Paulo, São Paulo, Brazil
ICESP
São Paulo, São Paulo, Brazil
Clinical complications
respiratory, cardiovascular, renal, neurological, infectious, surgical
Time frame: 30 days
Mortality
30-day mortality
Time frame: 30 days
Length of stay in ICU and in hospital
Length of stay
Time frame: 30 days
ICU readmission rate
ICU readmission rate
Time frame: 30 days
Duration of pharmacologic hemodynamic support
duration of vasopressor therapy
Time frame: 30 days
Levels of C-reactive protein
serum levels of C-reactive protein
Time frame: 7 days
Duration of mechanical ventilation
Duration of invasive mechanical ventilation
Time frame: 30 days
Liver dysfunction
liver dysfunction according SOFA
Time frame: 30 days
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