Effect of Sodium Bicarbonate on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass (OPCAB)

Yonsei University162 enrolled

Overview

In this single-site, randomized, controlled and double-blind clinical trial, the investigators evaluate the effect of sodium bicarbonate on prevention of acute kidney injury in high risk patients undergoing off pump coronary bypass surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

162

Conditions

Acute Kidney Injury

Interventions

sodium bicarbonateDRUG

BIVON group were received 0.5 mmol/kg of sodium bicarbonate for 1hours after induction of anesthesia and following 0.15 mmol/kg of sodium bicarbonate during the operation.

normal salineDRUG

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients older than 20 years * scheduled for elective coronary artery bypass grafting. * preoperative estimated glomerular filtration rate (eGFR) : 30 \~ 89 % * LVEF \< 35% * NYHA class III or IV * age \> 70 * DM * reoperation Exclusion Criteria: * acute renal impairment * patients who receive dialysis * patients who receive steroid ( \> 10mg/day prednisolon or equivalent) * hemo-alkalosis * hypernatremia * pulmonary edema * Hemoglobin \< 10 mg/dL

Locations (1)

Department of anesthesiology and pain medicine

Seoul, South Korea

Outcomes

Primary Outcomes

compare the incidence of acute kidney injury

The diagnostic criteria for AKI is followed by AKIN criteria (absolutely increase in the SCr concentration ≥ 0.3 mg/dL from baseline, ≥ 50% increase in the SCr concentration within 48 hours after operation).

Time frame: Change of Indexes of renal function including SCr, cystatin C, creatinine clearance from 24 hrs before operation to postoperative day (POD) 5.

Data from ClinicalTrials.gov

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