The purpose of this study is to investigate subjective sleep quality and fatigue during and after Acute uncomplicated diverticulitis assessed by questionnaires and a sleep-diary. The investigators hypothesis is that subjective sleep and fatigue are correlated with the inflammatory activities.
An increasing number of experimental studies have showed that inflammation can induce disturbances in sleep architecture, mediated by cytokines. some studies showed that cytokines also induce daytime fatigue. In this study the investigators aim to describe the patient experiences of sleep and fatigue during the acute inflammation and the recovery, and the investigators seek to exam the correlation of fatigue with Polysomnography-measured night sleep and cytokine levels in plasma. Following methods will be applied * Other: Karolinska Sleepiness Scale * Other: Physical Fatigue Scale * Other: Visual Analog Scale and 10 point-scales to measure fatigue, general well-being, subjective sleep and pain * Other: Sleep-diary * Device: Polysomnograph - Embla Titanium (Natus Medical Incorporated, USA) * Procedure: Plasma cytokines (IL-2, IL-6 and TNF-alfa(tumor necrosis factor)) * Procedure: Plasma CRP(C reactive protein) and leukocytes * Device: Wrist-Actigraph - Octagonal Basic Motionlogger, Ambulatory monitoring Inc, New York, USA
Study Type
OBSERVATIONAL
Enrollment
13
Department D, Herlev Hospital
Herlev, Copenhagen, Denmark
Changes in Sleep quality during acute uncomplicated diverticulitis from baseline score at remission (14th, 21st and 30th day)
1. subjective sleep quality measured by a Visual Analog Scale (VAS) at given time frame 2. sleep-diary recording sleep quantity of day and night sleep at given time frame
Time frame: 1st-10th day and 14th, 21st, 30th day following the admission
Changes in Sleepiness during acute uncomplicated diverticulitis from baseline score at remission (14th, 21st and 30th day)
Sleepiness measured by Karolinska Sleepiness Scale at given time frame
Time frame: 1st-10th day and 14th, 21st, 30th day following the admission
Changes in fatigue during acute uncomplicated diverticulitis from baseline score at remission (14th, 21st and 30th day)
1. General fatigue measured on Visual Analog Scale at given time frame 2. Physical fatigue measured on a 10 points scale at given time frame
Time frame: 1st-10th day and 14th, 21st, 30th day following the admission
Changes in general well-being during acute uncomplicated diverticulitis from baseline score at remission (14th, 21st and 30th day)
general well being measured on VAS
Time frame: 1st-10th day and 14th, 21st, 30th day following the admission
Changes in pain during acute uncomplicated diverticulitis from baseline score at remission (14th, 21st and 30th day)
Pain measured on VAS
Time frame: 1st-10th day and 14th, 21st, 30th day following the admission
accuracy of sleep diary compared to actigraph in measuring sleep data
Sleep quantity registered by the sleep diary compared with actigraph measured sleep quantity at given time frame
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Time frame: 1st-10th day and 14th, 21st, 30th day following the admission
accuracy of sleep diary compared to Polysomnography (PSG) in measuring sleep data
Sleep quantity registered by the sleep diary compared with PSG measured sleep quantity at given time frame
Time frame: 1st-2nd day and 30th day following the admission
correlation between fatigue and level of cytokines in patient's plasma
Investigator seek to find correlations between levels of IL-2, IL-6, TNF-alpha, CRP, Leucocytes and subjective fatigue measured by VAS and a 10 points scale.
Time frame: 1st and 2nd and 30th day following the admission
correlation between pain and level of cytokines in patient's plasma
Investigator seek to find correlations between levels of IL-2, IL-6, TNF-alpha, CRP, Leucocytes and subjective pain measured by VAS.
Time frame: 1st and 2nd and 30th day following the admission
correlation between sleepiness and level of cytokines in patient's plasma
Investigator seek to find correlations between levels of IL-2, IL-6, TNF-alpha, CRP, Leucocytes and subjective sleepiness measured by Karolinsk Sleepiness Scale
Time frame: 1st and 2nd and 30th day following the admission
correlation between general well-being and level of cytokines in patient's plasma
Investigator seek to find correlations between levels of IL-2, IL-6, TNF-alpha, CRP, Leucocytes and general well-being measured by VAS
Time frame: 1st and 2nd and 30th day following the admission