Efficacy and Tolerability of Anacetrapib Added to Ongoing Lipid-Lowering Therapy in Adult Participants With Homozygous Familial Hypercholesterolemia (HoFH) (MK-0859-042)

Inclusion Criteria: * Diagnosed with HoFH by genotyping * If female, cannot be of reproductive potential * Have been stabilized on statin monotherapy or statin therapy coadministered with other lipid medications for at least 6 weeks Exclusion Criteria: * Severe chronic heart failure defined by New York Heart Association (NYHA) Classes III or IV * Uncontrolled cardiac arrhythmias, myocardial infarction (MI), percutaneous coronary intervention (PCI), coronary arterial by-pass graft (CABG), unstable angina or stroke within 3 months prior to Visit 1 or has planned procedures scheduled within first 12 weeks of study * Uncontrolled endocrine or metabolic disease known to influence serum lipids or lipoproteins * Active or chronic hepatobiliary or gall bladder disease * History of ileal bypass, gastric bypass, or other significant condition associated with malabsorption * Human immunodeficiency virus (HIV) positive * Donated blood products or has had phlebotomy of \>300 mL within 8 weeks or intends to donate 250\_mL of blood products or receive blood products within the projected duration of the study * Taking medications that are potent inhibitors or inducers of cytochrome P450 3A4 (CYP3A4), including but not limited to cyclosporine, systemic itraconazole or ketoconazole, erythromycin, clarithromycin, or telithromycin, nefazodone, protease inhibitors, carbamazepine, phenobarbital, phenytoin, rifabutin, rifampin, St John's wort) or has discontinued treatment \<3 weeks prior. Consumption of \>1 liter of grapefruit juice per day is also prohibited. * Currently participating or has participated in a study with an investigational compound or device within 3 months * Consume more than 2 alcoholic drinks per day * Receiving treatment with systemic corticosteroids or systemic anabolic agents