Genetic Variability in Taste Perception

Monell Chemical Senses Center90 enrolled

Overview

This proposal describes a pilot study aimed at determining whether genetic variations in taste receptors determine differential taste tolerability of pediatric medications.

This is a cross-sectional call-back study of taste perception and the relationship between taste perception and taste receptor genotype.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Healthy

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adult females who were previously enrolled in Efficacy of Bitter Blockers on Taste Acceptance in Pediatric Populations Study (Protocol #809789) Exclusion Criteria: * Women who are pregnant * Women on drugs with potential serious adverse effects that are mediated through cytochrome P450.

Locations (1)

Monell Chemical Senses Center

Philadelphia, Pennsylvania, United States

Outcomes

Primary Outcomes

Psychophysical data for taste solutions

Primary outcome variables are intensity ratings of pediatric medications as well as a variety of generally recognized as safe bitter and non-bitter compounds.

Time frame: 1-2 hours

Secondary Outcomes

Maternal practices and perceptions of medication use

Secondary outcome variables include questions related to maternal practices and perceptions of medication use and compliance of their children.

Time frame: 1-2 hours

Data from ClinicalTrials.gov

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