Endometrial Scratching in In Vitro Fertilization Cycles With Oocyte Donation

Centro de Infertilidad y Reproducción Humana

Overview

This study is designed to evaluate the potential benefit in pregnancy rates produced by an endometrial scratching made in an IVF cycle prior to embryo transfer in patients with donated oocytes.

This is a randomized, comparative, prospective, double Blind study. The First stage of this study consists of revising the patients medical records to identify possible candidates. Patients indicated are randomized into two groups: experimental and control. They are followed up to 12 week of pregnancy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Conditions

Subfertility

Interventions

scratchingPROCEDURE

Endometrial Injury * Done between 18-24 days prior to embryo transfer cycle. * Using transfer catheter. * Introduction of the same to the uterine fundus. * Systematic scrapping of the four uterine walls, lengthwise. * Performed by a skilled doctor. * Subsequent ultrasound control.

Eligibility

Sex: FEMALEMin age: 21 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Do IVF cycle with donor eggs * Will adjust to protocol for the study. * Have signed informed consent Exclusion Criteria: * Clinically significant systemic disease, hypothalamic or pituitary tumors * ovarian, uterine or breast cancer * hormonal abnormalities and / or medical , biochemistry, hematology pathology, which might interfere with gonadotropin treatment. * known positivity for human immunodeficiency virus (HIV), hepatitis C or B virus (HCV / HBV) of the candidate or her partner. * Uterine Factor(submucosal fibroids, intramural fibroids\> 4 cm) * Hydrosalpinx * Patients receiving immune treatment * Positive Diagnosis Thrombophilia * preimplantation genetic diagnosis needed * In case of using marital sperm are excluded the following patients:Altered male karyotype, Altered Meiosis in testicular biopsy, Altered FISH, sperm Fragmentation\> 45% * Pregnancy contraindication * Known allergy to preparations containing estrogens or any of its excipients. * Simultaneous participation in another clinical trial with medication. * Do not want or can not adjust to study protocol.

Locations (1)

Centro de Infertilidad y Reproducción Humana

Barcelona, Spain

Outcomes

Primary Outcomes

biochemical pregnancy

Determination of human chorionic gonadotropin blood levels.

Time frame: 14-16 days post-follicular punction

Secondary Outcomes

Clinical pregnancy

Ultrasound

Time frame: 6 pregnancy weeks

Data from ClinicalTrials.gov

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