The Initial Effect of Training on Mitochondrial Function in Patients With Intermittent Claudication

Norwegian University of Science and Technology50 enrolled

Overview

The hypothesis of this study is that one bout of leg exercise gives acute qualitative changes in mitochondrial function in claudication. Final purpose is to determine the optimal exercise frequency in treatment of claudication.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Intermittent Claudication

Interventions

exerciseBEHAVIORAL

one bout of exercise training

Eligibility

Sex: ALLMin age: 50 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * A history of any type of uni- or bilateral exertion leg pain. * A maximal claudication distance that is less than 300 meter * Diagnosed with intermittent claudication secondary to vascular insufficiency * An ankle-brachial index between 0.4 and 0.9. * Lives in Trondheim Exclusion Criteria: * Diagnosed with critical limb ischemia * ankle-brachial index \> 0.90 or \< 0.4 * Limited exercise tolerance * Warfarin or heparin usage * Diabetes mellitus * Underwent a vascular intervention in the last 3 months * Active cancer, renal- or liver disease.

Locations (1)

Department for circulation and medical imaging, NTNU

Trondheim, Postboks 8905, Norway

Outcomes

Primary Outcomes

Mitochondrial function

respirometry

Time frame: One day

Data from ClinicalTrials.gov

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