The aim of this prospective randomized double-blind study was to compare the efficacy and safety of Botulinum toxin injection in epicardial fat pads for preventing recurrences (in early postoperative period) of atrial tachyarrhythmia in patients with paroxysmal atrial fibrillation undergoing coronary artery bypass graft (CABG) surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
The Valley Health System and Columbia University College of Physicians & Surgeons
New York, New York, United States
State Research Institute of Circulation Pathology
Novosibirsk, Russia
Institute of Cardiology, Siberian Division of Russian Academy of Medical Sciences
Tomsk, Russia
recurrence of > 30 secs of atrial tachyarrhythmia, including AF and atrial flutter/tachycardia, after CABG procedure on no antiarrhythmic drug
Time frame: 1 year
time intervals from end of surgery to weaning from ventilation, extubation and discharge from ICU
Time frame: 1 year
post-CABG length of stay
Time frame: 12 months
incidence of congestive heart failure
Time frame: 12 months
incidence of sustained ventricular arrhythmias
Time frame: 12 months
incidence of myocardial infarction
Time frame: 12 months
incidence of renal failure
Time frame: 12 months
incidence of respiratory failure
Time frame: 12 months
stroke or transient ischemic attack
Time frame: 12 months
rehospitalization
Time frame: 12 months
readmission to ICU
Time frame: 12 months
number of deaths
Time frame: 12 months
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post-CABG length of stay
Time frame: 1 year