Worldwide over 2 million adults (\>30,000 Canadians) undergo heart surgery annually. Although heart surgery provides important survival benefits, it is associated with potential major complications such as death, stroke, and heart attack. There is promising evidence that measurement of heart injury markers after surgery will identify patients at risk of death or major complications. This study will determine the current incidence of major complications in a representative sample of 15,000 contemporary adult patients undergoing heart surgery. Knowing the current burden of complications will inform clinicians, administrators, government and granting agencies about resources required to address the problem. This study will also establish the role of measuring heart injury markers to identify important heart injury after heart surgery and the proportion that would go undetected without routine heart injury marker monitoring. This information will facilitate further studies of timely interventions. In summary, the VISION Cardiac Surgery Study addresses fundamental questions that will have profound public health implications given the millions of adults worldwide who undergo heart surgery annually.
Study Type
OBSERVATIONAL
Enrollment
15,989
Ronald Reagan Medical Centre, UCLA
Los Angeles, California, United States
Royal Prince Alfred Hospital
Sydney, New South Wales, Australia
Hospital de Clínicas de Porto Alegre - HCPA
Porto Alegre, Rio Grande do Sul, Brazil
Instituto de Cardiologia do RS
Porto Alegre, Rio Grande do Sul, Brazil
INCOR
São Paulo, Brazil
Hamilton Health Sciences
Hamilton, Ontario, Canada
Kingston General Hospital
Kingston, Ontario, Canada
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
First Teaching Hospital
Xinjiang, China
Prince of Wales Hospital
Shatin, Hong Kong, SAR, Hong Kong
...and 14 more locations
All-cause mortality at 30-days after surgery
All-cause mortality at 30-days after surgery
Time frame: 30 days after surgery
Myocardial injuries that were not identified clinically during the first 5 days after surgery
Myocardial injuries that were not identified clinically during the first 5 days after surgery
Time frame: 5 days after surgery
Composite of vascular death, nonfatal myocardial infarction, nonfatal cardiac arrest, nonfatal stroke, and mechanical assist device
Major vascular complications at 30 days after surgery (i.e., a composite of vascular death, nonfatal myocardial infarction, nonfatal cardiac arrest, nonfatal stroke, and mechanical assist device)
Time frame: 30 days after surgery
Composite of vascular death, nonfatal myocardial infarction, nonfatal cardiac arrest, nonfatal stroke, and mechanical assist device
Major vascular complications at 1-year after surgery (i.e., a composite of vascular death, nonfatal myocardial infarction, nonfatal cardiac arrest, nonfatal stroke, and mechanical assist device)
Time frame: 1 year after surgery
Composite of vascular death, nonfatal myocardial infarction, nonfatal stroke, and mechanical assist device
Major vascular complications at 30-days after surgery (i.e., a composite of vascular death, nonfatal myocardial infarction, nonfatal stroke, and mechanical assist device)
Time frame: 30 days after surgery
Total mortality
Total mortality
Time frame: 30 days after surgery
Total mortality
Total mortality
Time frame: 1 year after surgery
Vascular mortality
death due to vascular cause
Time frame: 30 days after surgery
Vascular mortality
death due to vascular cause
Time frame: 1 year after surgery
Myocardial infarction
Myocardial infarction
Time frame: 30 days after surgery
Myocardial infarction
Myocardial infarction
Time frame: 1 year after surgery
Non-fatal cardiac arrest
Non-fatal cardiac arrest
Time frame: 30 days after surgery
Non-fatal cardiac arrest
Non-fatal cardiac arrest
Time frame: 1 year after surgery
Stroke
Stroke
Time frame: 30 days after surgery
Stroke
Stroke
Time frame: 1 year after surgery
Implantation of mechanical assist device
Implantation of mechanical assist device
Time frame: 30 days after surgery
Implantation of mechanical assist device
Implantation of mechanical assist device
Time frame: 1 year after surgery
Cardiac transplant
Cardiac transplant
Time frame: 30 days after surgery
Cardiac transplant
Cardiac transplant
Time frame: 1 year after surgery
Repeat cardiac revascularization procedures
Repeat cardiac revascularization procedures
Time frame: 30 days after surgery
Repeat cardiac revascularization procedures
Repeat cardiac revascularization procedures
Time frame: 1 year after surgery
Congestive heart failure
Congestive heart failure
Time frame: 30 days after surgery
Congestive heart failure
Congestive heart failure
Time frame: 1 year after surgery
New atrial fibrillation
New clinically important atrial fibrillation
Time frame: 30 days after surgery
New atrial fibrillation
New clinically important atrial fibrillation
Time frame: 1 year after surgery
Pulmonary embolus
Pulmonary embolus
Time frame: 30 days after surgery
Pulmonary embolus
Pulmonary embolus
Time frame: 1 year after surgery
Deep venous thrombosis
Deep venous thrombosis
Time frame: 30 days after surgery
Deep venous thrombosis
Deep venous thrombosis
Time frame: 1 year after surgery
Major bleeding
Major bleeding
Time frame: 30 days after surgery
Major bleeding
Major bleeding
Time frame: 1 year after surgery
New dialysis
New dialysis
Time frame: 30 days after surgery
New dialysis
New dialysis
Time frame: 1 year after surgery
Infection
Infection (including sternal, sepsis, pneumonia)
Time frame: 30 days after surgery
Infection
Infection (including sternal, sepsis, pneumonia)
Time frame: 1 year after surgery
Re-hospitalization for a vascular reason
Re-hospitalization for a vascular reason
Time frame: 30 days after surgery
Re-hospitalization for a vascular reason
Re-hospitalization for a vascular reason
Time frame: 1 year after surgery
Chronic incisional pain
Chronic incisional pain
Time frame: 30 days after surgery
Chronic incisional pain
Chronic incisional pain
Time frame: 1 year after surgery
Frailty
Frailty assessed by PRISMA-7 questionnaire
Time frame: 30 days after surgery
Frailty
Frailty assessed by PRISMA-7 questionnaire
Time frame: 1 year after surgery
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