MicroRNAs as Biomarkers in Patients With Chagas Disease

Inclusion Criteria: * Chagas disease diagnosis confirmed by 2 different serologies * Diagnosis of Chagas disease in both forms: indeterminate and cardiac ones, with and without ventricular dysfunction. Exclusion Criteria: * Significant valve disease defined as aortic stenosis with a gradient of VE/Ao \> 50 mmHg * Mitral stenosis with a valve area inferior than 1,5 cm2 * Severe or moderate aortic and/or mitral regurgitation * Chronic use of immunosuppressive agents * Dialysis treatment of terminal renal failure * Fever on the last 48 hours or evidence of systemic infection in activity according to the definition of sepsis of the ACCP/SCCM (American College os Chest Physicians/Society of Critical Care Medicine) * Current abusive use of alcohol or illicit drugs (Based on the DSM IV) * Any other comorbidities that impact patient's survival within the next 2 years * Liver disease in activity * Continuous use of steroids as treatment for COPD * Hematologic, neoplastic or bone diseases * Homeostasis disturbances * Inflammatory diseases or chronic infectious diseases