Usefulness of Flospan as a premedication for colonoscopy: A randomized double-blind controlled trial
Cimetropium bromide is premedication of colonoscopy. However, it is contraindication for some diseases; benign prostatic hyperplasia(BPH) or other obstructive uropathy, intestinal obstruction, pyloric stenosis, glaucoma, myasthenia gravis, megacolon, paralytic ileus. In this cases, Flospan (phloroglucin) is effective alternative drug. So our research was to compare the effects of these two drugs.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
TRIPLE
Enrollment
260
Premedication of colonoscopy
Premedication of colonoscopy
Diagnostic examination of colon
Ajou University Hospital
Suwon, South Korea
RECRUITINGNon inferiority of phloroglucin to cimetropium bromide
Comparing the two groups of time of examination, frequency of peristalsis, Scoring for the experimenter and the subject of the inspection feedback, double-blind setting.
Time frame: Up to ten months
Total diagnostic colonoscopy exam time
Time frame: 1 year
Evaluation of practitioners
Colonic motility and test difficulty
Time frame: 1 year
Evaluation of subjects
The degree of discomfort after test
Time frame: 1 year
Peristalsis time of transverse colon
Total peristalsis time of transverse colon for two minutes
Time frame: 1 year
Total dose and times of sedatives for pain control
Total dose and times of sedatives (midazolam, propofol) for pain control
Time frame: 1 year
Time of cecal intubation
Total time of colonoscope intubation from anus to cecum
Time frame: 1 year
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Placebo for double-blind study These are harmless to the human body, and are composed of saline solution without drug efficacy.