The aim of this study is evaluate the feasibility of early two-stage hepatectomy in patients with liver metastasis from colorectal cancer.
In France, each year around 36,000 new cases of colorectal cancers are registered responsible in 16,000 deaths because of liver metastasis. In case of bilobar metastasis, classic two-stage hepatectomy with portal embolization could be performed. An alternative to the classic surgery, early two stage hepatectomy, could be proposed to simplify the patient's management and to improve the resectability.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
3
Amiens University Hospital
Amiens, France
number of complete surgical procedure
the number of complete surgical procedure is defined as the number of patients in whom the two stage hepatectomy is complete.
Time frame: postoperative week 4
overall mortality
the overall mortality is defined as the number of patients who are dead at one year after the surgery
Time frame: one year after the two stage hepatectomy
number of patient with hepatocellular insufficiency
the hepatocellular insufficiency is defined by a prothrombin rate below 50%
Time frame: postoperative day 30
overall morbidity
the overall morbidity is classified according to the Dindo Clavien classification
Time frame: postoperative day 30
preoperative liver volumetry
the remnant liver volume is evaluated with the Myrian Software and calculated by the radiologist
Time frame: one week prior to the surgery
quality of life
the quality of life is evaluated thanks to the EORTC QLQ C30 LMC 21 form the day before the first stage surgery and the day before the second stage surgery.
Time frame: the day before the first stage surgery and the day before the second stage surgery
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