Effects of Addition of Magnesium Sulfate in Spinal Anesthesia on Sensory-Motor Blocks and Postoperative Pain in Lumbar Disk Herniation Surgery

Isfahan University of Medical Sciences105 enrolled

Overview

The purpose of this study is to Compare three methods of intrathecal bupivacaine; bupivacaine-fentanyl; bupivacaine-fentanyl-magnesium sulfate on sensory-motor blocks and postoperative pain in patients undergoing lumbar disk herniation surgery.

* Comparison three methods of intrathecal bupivacaine;bupivacaine-fentanyl;bupivacaine-fentanyl-magnesium sulfate on sensory-motor blocks in patients undergoing lumbar disk herniation surgery * Comparison three methods of intrathecal bupivacaine;bupivacaine-fentanyl;bupivacaine-fentanyl-magnesium sulfate on postoperative pain in patients undergoing lumbar disk herniation surgery * Comparison three methods of intrathecal bupivacaine;bupivacaine-fentanyl;bupivacaine-fentanyl-magnesium sulfate on postoperative side effects in patients undergoing lumbar disk herniation surgery

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE

Enrollment

105

Conditions

Lumbar Spine Disc Herniation

Interventions

Magnesium SulfateDRUG

Injection of 50 mg of magnesium sulfate 50% (0.1 ml),intrathecally.

Spinal AnesthesiaPROCEDURE

Lumbar puncture was performed in sitting position,at the one level above iliac crest. Using a median approach, a 25-G Quincke needle was introduced with the needle aperture directed laterally.

BupivacaineDRUG

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Candidate for lumbar disk herniation surgery * No contraindication to the spinal anesthesia * No history of allergy to opioids and magnesium sulfate * No peripheral or central neuropathies * No previous history of surgery on same disk level Exclusion Criteria: * Patients with intraoperative tearing of dural suc * Occuring of inadvertent intraoperative complications such as bleeding

Locations (1)

Alzahra

Isfahan, Isfahan, Iran

Outcomes

Primary Outcomes

The onset of sensory block

Comparing the onset of sensory blocks to T10 (10th thoracic dermatome) assessed by pinprick test.

Time frame: From intrathecal injection until the onset of sensory block assessed up to 15 minutes

The complete motor block

Time to complete motor block after intrathecal injection as assess using a modified Bromage scale

Time frame: From intrathecal injection until the onset of complete motor block assessed up to 15 minutes

The sensory block regression

The sensory block regression to (T10) dermatome

Time frame: From intrathecal injection until the sensory block reression to (T10) assessed up to 6 hours

The full motor recovery

Full motor recovery was defined as zero on the Bromage scale.

Time frame: From intrathecal injection until the full motor recovery assessed up to 6 hours

The Pain Score

Using VAS (Visual Analogue Score) system

Time frame: The first 24 hours after spinal anesthesia

Time to first analgesic requirement

Time to first analgesic requirement was measured from the time of spinal injection to the first time at which the patient complained of pain in the postoperative period

Time frame: During first 24 hours after spinal anesthesia

Secondary Outcomes

Mean Arterial Blood Pressure

To compare blood pressure alteration and hypotension between three groups

Time frame: First hour after spinal anesthesia

Data from ClinicalTrials.gov

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