Uterus Transplantation From Live Donor

Sahlgrenska University Hospital9 enrolled

Overview

Uterus transplantation, as a possible future treatment for uterine factor infertility, has been developed in animal species during the last decade. The study protocol includes transplantation of the uterus from a live donor (mother, relative, friend) into women with absolute uterine factor infertility (lack of uterus from birth or due to life saving hysterectomy).The recipient will be treated by standard immunosuppression and transfer of embryos (acquired by IVF before surgery) will be attempted when at least 12 months have passed from transplantation. Approval for a case series including up to 10 patients has been acquired.

The study is ongoing, with inclusion of 9 patients.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Primary Uterine Infertility

Interventions

uterine transplantationPROCEDURE

Transplantation of the uterus from live donor and IVF treatment.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 39 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * less than 39 years * good general health Exclusion Criteria: * poor ovarian resaerve or older than 39 years * systemic or psychiatric disease

Locations (1)

Mats Brännström

Gothenburg, Sweden

Outcomes

Primary Outcomes

surviving transplants (12 months)

Time frame: up to 3 years after transplantation

Secondary Outcomes

pregnancy rate

Time frame: up to 3 years after transplantation

Data from ClinicalTrials.gov

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