Clinical Applications of Domperidone in Patients With Delayed Gastric Emptying

Mt. Sinai Medical Center, Miami37 enrolled

Overview

The purpose of the study is to treat patients with on-going slow stomach emptying(gastroesophageal reflux disease), who have failed to respond to standard therapy

This is a study on the effectiveness of domperidone, which increases movement through the digestive system for relief of symptoms, in patients who have delayed gastric solid-phase emptying

Study Type

INTERVENTIONAL

Allocation

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Digestive System Disease

Interventions

DomperidoneOTHER

Domperidone dosage may be increased depending on how well the patient responds. However before increasing the dosage, patients will have follow-up EKG to evaluate any possible side effects including irregular heartbeats.

Eligibility

Sex: ALLMin age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Persistent esophagitis * Heartburn * Nausea * Vomiting * Severe dyspepsia * Severe chronic constipation Exclusion Criteria: * History of, or current arrhythmias including ventricular tachycardia, - Ventricular fibrillation and Torsade des Pointes.

Locations (2)

Division of Gastroenterology, Mt. Sinai Medical Center

Miami Beach, Florida, United States

Mt. Sinai Medical Center, Division of Gastroenterology

Miami Beach, Florida, United States

Outcomes

Primary Outcomes

Clinical Applications of Domperidone in Patients with Refractory Gastroesophageal Reflux Disease (GERD)or Delayed Gastric Solid-Phase Emptying

GERD or Delayed Gastric Emptying

Time frame: 5 years

Data from ClinicalTrials.gov

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