Laboratory Study of Cannabidiol on the Effects of Smoked Marijuana

National Institute on Drug Abuse (NIDA)50 enrolled

Overview

The objective of this study is to assess the effects of oral cannabidiol (CBD; 0, 200, 400, 800 mg) on smoked marijuana's (0, 5.6% THC) subjective, reinforcing, cognitive, and cardiovascular effects. This experiment is expected to reveal CBD's intrinsic effects when combined with placebo marijuana, as well as its ability to modulate the behavioral effects of active marijuana.

Marijuana contains many chemicals called cannabinoids. The ingredient mainly responsible for marijuana's psychoactive effects is called THC (delta-9-tetrahydrocannabinol. Another cannabinoid in marijuana is cannabidiol. It is found in smaller quantities than THC. Cannabidiol is thought to interfere with the effects of THC. Therefore, synthetically produced cannabidiol is given to healthy marijuana users in this study to test its capability to reduce the high of THC and, thereby, help to relieve addiction to marijuana.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Smoking, Marijuana

Interventions

CBDDRUG

Each subject in the study was tested on eight days, each day receiving a different combination of active/inactive cannabis cigarettes plus 0, 200, 400 or 800 mg of CBD in random order. Cigarettes contained either 0.01 or 5.30% THC. At each visit, participants were given four gelatin capsules containing lactose and 0 or 200 mg of CBD in combinations to achieve scheduled dose level.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults between the ages of 18 and 50. * Current marijuana use: Minimum of four times per week, 0.5 joints per occasion during the preceding 4 weeks. * Able to perform study procedures * Women practicing an effective form of birth control Exclusion Criteria: * Female subjects who are currently pregnant or breastfeeding. * Current, repeated illicit drug use other than marijuana * Presence of significant medical illness * History of heart disease * Request for drug treatment * Current parole or probation * Recent history of significant violent behavior * Major psychiatric disorder

Locations (3)

University of Kentucky, Straus Behavioral Research Bldg., 515 Oldham Ct.

Lexington, Kentucky, United States

Marijuana Outpatient Lab 1051 Riverside Dr. Unit #120

New York, New York, United States

Center for Drug and Alcohol Programs, Room 459 North, 67 President St.

Charleston, South Carolina, United States

Outcomes

Primary Outcomes

Mood Scale - Subscale 'Feeling High'

Participants rated how much they felt having a "high" feeling from smoked marijuana using a visual analog scale 1-100 mm, 1 (Not at all) - 100 (extremely).

Time frame: two hours before and after marijuana cigarette smoking

Data from ClinicalTrials.gov

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