The purpose of this study is to investigate the effects of a combined training programme and a high intensity interval training programme on insulin resistance, muscle strength/ muscle contractile properties, aerobic capacity and body composition in MS patients. It is assumed that the the above mentioned clinical parameters will improve due to physical exercise.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
34
Reval
Diepenbeek, Belgium
insulin sensitivity (insulin profile)
glucose and insulin concentration measurements in blood
Time frame: change from baseline to 12 weeks
muscle contractile properties
measurements of cross sectional area and fiber distribution in muscle fibers of the m. vastus lateralis + measurements of enzymatic reactions, ATP, glycogen, ...
Time frame: from baseline to 12 weeks
muscle strength of knee extensor/flexor
by means of an isokinetic dynamometer the muscle strength and endurance will be measured
Time frame: change from baseline to 12 weeks
aerobic capacity
by means of a submaximal endurance test (ergometer)
Time frame: change from baseline to 12 weeks
cytokine profile
measurements of blood cytokine levels
Time frame: change from baseline to 12 weeks
Self-reported measures
The self-reported measures contains some questionnaires
Time frame: Change from baseline to 12 weeks
body composition
Weight, body fat% and lean tissue% will be assessed by means of a DEXA scan
Time frame: Change from baseline to 12 weeks
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