Sodium Intake in Multiple Sclerosis

Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia132 enrolled

Overview

Recently, it has been shown that salt (ClNa, sodium chloride) can modulate the differentiation of human and mouse TH17 cells. Indeed, mice feed with high sodium diet were described to develop more aggressive course of EAE (Experimental Autoimmune Encephalitis). However, the role of sodium intake in MS has not been investigated. In this study we investigate the effect of sodium intake in Multiple Sclerosis (MS) clinical and radiological activity.

Study Type

OBSERVATIONAL

Enrollment

132

Conditions

Multiple Sclerosis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Subject is between 18 and 50 years old * Subject has diagnosis of relapsing-remitting MS according to McDonald criteria (2010) Exclusion Criteria: * Patient who had hyponatremia in the last 90 days

Locations (1)

FLENI

Buenos Aires, Argentina

Outcomes

Primary Outcomes

Exacerbation rate

Number of disease relapses during follow up time according to salt consumption

Time frame: 2 years

Secondary Outcomes

Radiological activity

Number of new lesions in MRI

Time frame: One year

Data from ClinicalTrials.gov

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