The Effects of Administration of Combined Docosahexaenoic Acid and Vitamin E Supplements on Spermatogram and Seminal Plasma Oxidative Stress in Infertile Men With Asthenozoospermia

National Nutrition and Food Technology Institute180 enrolled

Overview

Since docosahexaenoic acid (DHA) level in sperm membrane has been shown to be decreased in asthenozoospermic men, the investigators hypothesized that DHA supplementation may improve it. Furthermore, the investigators added vitamin E to it to protect its unsaturated bonds which are susceptible to oxidation and production of free oxygen radicals.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

180

Conditions

Asthenozoospermia

Interventions

vitamin EDIETARY_SUPPLEMENT

DHADIETARY_SUPPLEMENT

placeboOTHER

Eligibility

Sex: MALEMin age: 20 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion criteria: * Willing to participate in the study and filling out the informed consent form * should be infertile (no conception after 12 months intercourse without any contraception) * age 20-45 y.o, idiopathic asthenospermia according to WHO criteria * normal hormonal profile Exclusion criteria: * any infection in genitourinary (GU) tract * any anatomical abnormality in GU tract * any chronic disease during last 3 months * any surgery in GU tract * consumption of omega-3 fatty acids and/or vitamin E supplements during last 3 months

Outcomes

Primary Outcomes

sperm motility

spermatogram

Time frame: 12 weeks

Secondary Outcomes

sperm count

spermatogram

Time frame: 12 weeks

seminal oxidative stress

ELISA

Time frame: 12 weeks

Data from ClinicalTrials.gov

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