Oral Bicarbonate as Adjuvant for Pain Reduction in Patients With Tumor Related Pain

Inclusion Criteria: * Patients must have metastatic or unresectable solid malignancy or hematologic malignancy (multiple myeloma or lymphoma) and must have moderate to severe tumor related pain visual assessment scale (VAS)\>4) on a stable or no opioid regimen (at least 3 days of an opiate regimen). VAS score should be greater than 4 at screening to be eligible. * No planned palliative surgery, palliative radiotherapy for at least 4 weeks. However prior radiotherapy, and surgery is allowed and not limited to the number of procedures and courses. Concomitant chemotherapy with agents indicated in protocol guidelines (Tables 10 and 11B, Appendix IV) is allowed. * No evidence of neurologic or psychiatric compromise which in the opinion of the investigator will interfere with completion of study assessments * Age greater than 18 years and able to understand and sign the informed consent document * Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status less than 3. * A female patient and a male patient's female partner, of childbearing potential, must agree to use 2 adequate barrier methods of contraception to prevent pregnancy or to abstain from heterosexual activity throughout the study, starting from Visit 1, while receiving protocol-specified medication, and for 1 month after stopping the medication. Exclusion Criteria: * Patients with neuropathy and/or neuropathic pain as the only pain syndrome are not eligible. * Patients with only chronic non-malignant pain are not eligible. * Patients with renal insufficiency (creatinine \> 2.5mg/dL) are excluded. * Patients with history of congestive heart failure or pulmonary artery hypertension will be excluded. * Patients with uncontrolled hypertension (systolic pressure \>160, diastolic pressure \>100) despite maximal antihypertensive therapy * Patients unable to ingest sodium bicarbonate capsules (such as patients with dysphagia or severe nausea) * Patients with ECOG performance status 3 or higher * Patients with acute leukemia, myelodysplastic syndrome, and chronic myeloid leukemia are not eligible. * Pregnant or lactating patients are not eligible. * Patients with known allergy to sodium bicarbonate or patients with preexisting renal or acid base disorders for which sodium bicarbonate is contraindicated (such as metabolic alkalosis, severe congestive heart failure, hypernatremia, and hypocalcemia (see above)) * Patients with severe ongoing infections which places the patients at increased risks from therapy in the opinion of the investigator * Patients receiving concomitant chemotherapy with agents indicated in protocol guidelines (Tables 10 and 11B, Appendix IV) or target therapy intended to prolong life within 2 weeks of starting the study drug * Patients receiving experimental therapy within 2 weeks of starting study treatment