Effects of Protein Blends on Muscle Protein Synthesis in Healthy Older Adults

DuPont Nutrition and Health20 enrolled

Overview

During aging there is a tendency for muscle protein synthesis (growth) to become less efficient and the resulting consequence leads to reduced muscle mass (sarcopenia) which can affect strength and mobility. Protein consumption may be one opportunity to alleviate this problem especially when consumed in appropriate amounts following resistance training. This study is designed to determine if a soy dairy protein blend, shown to be effective in younger adults, will produce beneficial muscle protein synthesis in older healthy adults following resistance exercise.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

QUADRUPLE

Enrollment

Conditions

Muscle Synthesis

Interventions

Soy Dairy Protein BlendDIETARY_SUPPLEMENT

Positive Control (Dairy Whey Protein)DIETARY_SUPPLEMENT

Eligibility

Sex: MALEMin age: 55 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 55-70 yr olds Stable Body weight Exclusion Criteria: 1. Exercise training (\>2 weekly sessions of moderate to high intensity aerobic or resistance exercise) 2. Significant heart, liver, kidney, blood, respiratory disease or thyroid issues 3. Peripheral vascular disease 4. Orthopedic injury that prohibits participation in the exercise training 5. Diabetes mellitus or other untreated endocrine disease 6. Active cancer (all groups) and history of cancer 7. Acute infectious disease or history of chronic infections (e.g. TB, hepatitis, HIV, herpes) 8. Neurologic Injury or disease 9. Recent (within 6 months) treatment with anabolic steroids, or corticosteroids. 10. Alcohol or drug abuse 11. Tobacco use (smoking or chewing) 12. Malnutrition (BMI \< 20 kg/m2, hypoalbuminemia, and/or hypotransferrinemia) 13. Obesity (BMI \> 30 kg/m2) 14. Low hemoglobin levels (below normal values) 15. Food allergies 16. Taking dietary supplements such as green tea, omega 3 fatty acids, etc. 17. Females

Locations (1)

University of Texas Medical Branch

Galveston, Texas, United States

Outcomes

Primary Outcomes

Fractional Synthetic Rate (Muscle Protein Synthesis)

The fractional synthesis rate (FSR) of mixed muscle proteins will be calculated from the incorporation rate of L-\[ring-13C6\]Phenylalanine into the mixed muscle proteins, and the free-tissue phenylalanine enrichment.

Time frame: baseline, 3 hrs, 5 hrs

Secondary Outcomes

Anti-inflammatory and Anti-oxidant Markers

Proteins will be assessed that are markers of oxidative damage and inflammation (NFkB, IL-1, IL-6) and proteolysis (MuRF, MAFBx).

Time frame: baseline, 3 hrs, 5 hrs

Intracellular Signalling Genes and Proteins

Phosphorylation of Mammalian Target of Rapamycin (mTOR) pathway will be measured using Western blot techniques

Time frame: baseline, 3 hrs, 5 hrs

Data from ClinicalTrials.gov

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