Study to Assess Efficacy and Safety of BNX Sublingual Tablets for the Induction of Treatment of Opioid Dependence

Inclusion Criteria: * Able to read, comprehend, and sign the informed consent form and willingly provide written informed consent * Prepared to engage in opioid replacement therapy and to abstain from opioid utilization other than the study drug, and from other illicit drugs * Male or female, 18 to 65 years of age (inclusive) * Met clinical criteria for opioid dependence in past 12 months based on DSM-IV-TR * Provided buprenorphine-negative urine drug screen prior to randomization * Provided negative urine pregnancy test * Females of childbearing potential were required to be using a reliable method of contraception (e.g., hormonal, condom with spermicide, intrauterine device \[IUD\]) after the screening visit and for the duration of the study * Participants receiving opioids for pain must receive clearance from their prescribing physician to be withdrawn from their prescribed opioids * Generally good health as determined by the investigator * Participants should demonstrate at least mild withdrawal symptoms (defined as a COWS score \>9 at Day 1 predose) Exclusion Criteria: * Females who are pregnant or lactating, or planning to be pregnant during study * Any previous prescribed treatment with buprenorphine monotherapy (e.g., generic buprenorphine sublingual tablets) * Prescribed treatment with buprenorphine or naloxone within 90 days prior to start of treatment * Methadone patients with any daily dose over 30 mg during the past week and who received the last dose of methadone less than 30 hours prior to start of treatment * Participants who are unwilling or unable to comply with the requirements of the protocol * Participants who are participating in any other clinical study in which medication(s) are being delivered or who have used an investigational drug or device within the last 30 days * Participants with any known allergy or sensitivity or intolerance to buprenorphine, naloxone, or any related drug * Participants who are on the staff, affiliated with, or a family member of the staff personnel directly involved with this study * Participants with serious untreated Axis I DSM-IV-TR psychiatric comorbidity * Tongue piercing or other piercings in the mouth, including lips and cheek * Participants with current or history of clinically significant medical disorder or condition * Participants who are human immunodeficiency virus (HIV)-seropositive with a CD4+ count \<200 or active acquired immune deficiency syndrome (AIDS) * Participants who have any Class III or IV congestive heart failure, symptomatic myocardial ischemia, a history of long QT syndrome. * Participants who are currently taking Class 1A antiarrhythmic medications or Class III antiarrhythmic medications * Participants who have uncontrolled hypertension or clinically significant ECG abnormalities * Participants who have a pulse oximetry ≤93% at screening, due to any medical reason. * Individuals with AST or ALT levels ≥3 X the upper limit of normal or total bilirubin or creatinine ≥1.5 X ULN, on the screening laboratory assessments * Participants with known significant liver disease. * Participants who take any medication, nutraceutical, herbal product with known CYP3A4 inhibition or induction properties within 14 days of screening. * Participants who are at suicidal risk