Randomized Study on the Effects of Moderate Anaemia in Free Microvascular Tissue Transfer

University of Zurich

Overview

The evaluation of Perfusion of free flaps in patients with moderate anaemia and possible reduction of the transfusion threshold. * Trial with surgical intervention

In study group 1 patients will be kept at a hematocrit level below 28% and only receive transfusions if symptomatic or the fall below 25%. Patients in group 2 will receive transfusions to reach a hematocrit always above 30%. Tissue perfusion in free flaps will be measured with indocyanine green fluorescence angiography, confocal microscopy and oxygen partial pressure measurement probes.

Study Type

OBSERVATIONAL

Conditions

Open Fracture of Foot Tumor

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion criteria: * planned defect reconstruction with free flap and preoperative hematocrit of 28% or below Exclusion criteria: * coagulation disorder * Jehovah's witness * iodine allergy * renal or hepatic insufficiency

Locations (1)

University Hospital Zurich, Center for Reconstructive Surgery

Zurich, Canton of Zurich, Switzerland

Outcomes

Primary Outcomes

Number of Blood transfusions peri- and postoperative

Time frame: 10 days

Data from ClinicalTrials.gov

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