Study of the Effect of GS-6615 in Subjects With LQT-3

Inclusion Criteria: 1. Males and females between ages 18-65 years (inclusive) at time of screening 2. Documented LQT-3 genotype with one of the following mutations: delta KPQ, R1623Q, N1325S, E1784K, S1787N, D1790G, G1631D, 1795insD, delF1617, R1644H, L409P, F2004L, I1768V, T1304M, A1330T, or F1596I3. 3. QTc \> 480 msec in lead V5 at screening 4. Weight of at least 50 kg with body mass index (BMI) between 18 and 30 kg/m\^2 (inclusive) 5. Females of childbearing potential must have a negative serum pregnancy test at screening and check-in 6. Females of childbearing potential must agree to utilize protocol recommended highly effective contraception methods from three weeks prior to the single dose of study drug and for 30 days following the single dose of study drug a. Females who utilize hormonal contraceptive as one of their birth control methods must have used the same method for at least 3 months prior to study dosing 7. Males must agree to utilize a protocol recommended highly effective method of contraception during heterosexual intercourse throughout the study period and for 90 days following last dose of study drug. Periodic abstinence and withdrawal are not acceptable methods of contraception 8. Males must refrain from sperm donation from Day -2 through completion of the study and continuing for at least 90 days from the date of last dose of study drug 9. Willing and able to comply with the requirements of the protocol and directions from the clinic staff 10. Willing to avoid consumption of grapefruit, grapefruit juice and Seville oranges within 2 weeks prior to the single dose of study drug until discharge from the clinic 11. Willing to avoid consumption of nicotine (including nicotine gum) and alcoholic beverages within 2 weeks prior to the single dose of study drug until discharge from the clinic 12. Understand and willing to sign informed consent Exclusion Criteria: 1. Ongoing or history of any medical or surgical condition that, in the judgment of the Investigator, might jeopardize the individual's safety or interfere with the absorption, distribution, metabolism or excretion of the study drug 2. History of meningitis or encephalitis, seizures, migraines, tremors, myoclonic jerks, sleep disorder, anxiety, syncope, head injuries or a family history of seizures 3. Any abnormal electrocardiographic (ECG) findings (except QTc \> 460 msec) at screening judged to be clinically significant by the investigator 4. Any abnormal laboratory value or physical examination finding at screening or check-in that is judged by the investigator as clinically significant 5. History of positive serology test for HIV, or hepatitis B or C 6. Positive urine drug test for ethanol, barbiturates, cocaine, opiates, or amphetamines at screening or check-in 7. Positive urine cotinine test at check-in 8. Current treatment with drugs affecting the QT interval 9. Current treatment with sodium-channel blockers, eg, flecainide and mexiletine 10. Current treatment with strong or moderate inhibitors or inducers of cytochrome P450 (CYP)3A4 and 1A2 11. Prior treatment with ranolazine within 7 days prior to study drug administration 12. Use of systemic prescription medications or over-the-counter (OTC) medication, including multivitamins, and dietary and herbal supplement within 2 weeks or 5 times the terminal half-lives of the medication (whichever is longer) prior to the single dose of study drug, and for the duration of the study 13. Use of any experimental or investigational drug or device within 30 days prior to the single dose of study drug or 5 half-lives of the drug, whichever is longer 14. Females who are pregnant or lactating 15. History of drug or alcohol abuse within 12 months prior to initial dosing of study drug 16. Psychosocial or addictive disorders that would interfere with ability to give informed consent or could compromise compliance with the protocol