Vascular Risk Factors in INPH-patients

Umeå University860 enrolled

Overview

Idiopathic normal pressure hydrocephalus (INPH) is a treatable and a common disease of the elderly. The overall objective of this work is to describe cardio- and cerebrovascular risk factors and vascular disease in shunted INPH-patients compared to an age- and sex matched elderly population, as well as the impact of vascular risk factors and vascular co-morbidity on clinical symptoms and outcome of surgery in INPH-patients. The hypothesis is that INPH-patients have a higher level of vascular risk factors and subclinical organ damage than a normal elderly population, and that the higher the level of existing vascular risk factors, the more severe the symptoms of the hydrocephalic disease.

Study Type

OBSERVATIONAL

Enrollment

860

Conditions

Hydrocephalus, Normal Pressure Vascular Diseases Brain Diseases Central Nervous System Diseases Nervous System Diseases

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * INPH-patients who underwent surgery 2008-2010 and registered in the Swedish National Register of Hydrocephalus * age \<60 and \>85 * (only for controls) living in Umeå Exclusion Criteria: * death * a known mini mental state estimation \<23 * inability to communicate (because of severe stroke, aphasia, dementia) * (only for controls) individuals with INPH who has not yet underwent surgery, or has not been chosen to undergo surgery.

Outcomes

Primary Outcomes

Differences in bloodpressure between INPH-patients and a sex- and agematched community based population

Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013.

Time frame: More than two weeks, not longer than 6 months.

Secondary Outcomes

Quality of Life in INPH-patients compared to a sex- and age-matched population.

Time frame: More than 2 weeks, not longer than 6 months.