The Relationships Between the Noradrenergic, Opioid and Pain System

Rambam Health Care Campus

Overview

The role of alpha2 receptor agonist on pain perception and modulation will be examined. In addition whether this is mediated through the opioid system will be examined. Pain perception and modulation will be examined before and after administration of Clonidine or placebo together with Naloxone or saline.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Conditions

Experimental Pain Perception

Interventions

ClonidineDRUG

Clonidine 0.15 mg

NaloxoneDRUG

naloxone 0.15 mg/kg

placeboDRUG

salineOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers * Age 18-40 * No chronic disease Exclusion Criteria: * Subjects who suffer from chronic pain / pain syndrome * use of anti-depressant or anti-psychotic drugs * suffering from cardiovascular disease * breast feeding

Locations (1)

Rambam Health Care Campus

Haifa, Israel

Outcomes

Primary Outcomes

The changes in pain responses after administration of alpha 2 agonist and mu receptor antagonist

The change in pain perception (pain thresholds and pain ratings of suprathresholds stimuli) and in the excitatory and inhibitory pain modulation responses (assessed by the temporal summation and conditioned pain modulation paradigms) will be examined before and after administration of alpha 2 agonist with and without mu receptor antagonist

Time frame: 2 years

Data from ClinicalTrials.gov

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